HUMAN CLINICAL TRIALS

Our laboratory is focused on developing treatments and improved assessment tools for the neuromuscular diseases. We have been involved in a number of clinical therapeutic trials in amyotrophic lateral sclerosis and in other multicenter studies developing improved technologies. We have a specific interest in tools that can help assess the effects of therapy, including quantitative ultrasound technologies and electrical impedance myography. Many of these tools are still being refined, and thus our research continues to be an iterative process in which early versions of engineering concepts are applied, data collected and analyzed, refinements made the testing repeated. Like all science, our process of discovery takes place in irregular patterns; many small steps before an unexpected greater leap occurs.
Here are some images from recent and not-so-recent human studies with which we have initiated or with which our laboratory has been deeply involved.

Child undergoing electrical impedance myography of the left forearm

Child undergoing electrical impedance myography of the left forearm

QUS being performed on the tibialis anterior of a healthy boy

QUS being performed on the tibialis anterior of a healthy boy

A boy with DMD

A boy with DMD

Healthy infant undergoing electrical impedance myography as part of the NIH-funded NeuroNEXT spinal

Healthy infant undergoing electrical impedance myography as part of the NIH-funded NeuroNEXT spinal muscular atrophy biomarker study.

Electrical impedance myography being performed on an adult; the system shown is produced

Electrical impedance myography being performed on an adult; the system shown is produced by Myolex, Inc.

ALS-at-Home Study Logo and at-home EIM based fitness tool.

ALS-at-Home Study Logo and at-home EIM based fitness tool.

Evidence of disease progression in a group of 3 patients participating in ALS at home study,

Evidence of disease progression in a group of 3 patients participating in ALS at home study,

Below image is showing potential of obtaining frequent measurements to speed clinical trials.

showing potential of obtaining frequent measurements to speed clinical trials.
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